Journal: Endocrine Connections
Article Title: Rapid and selective gut microbiome modulation by polyherbal formulation in type 2 diabetes
doi: 10.1530/EC-25-0463
Figure Lengend Snippet: CCA and taxonomic composition of the gut microbiome. (A) CCA of gut microbiome profiles in PHF-treated patients (salmon) and the placebo group (pale green) before and after the 7-day intervention. Time points are distinguished by shape: circles indicate the baseline (before intervention) and triangles indicate the post-intervention period. The colored ellipses represent grouping by study arm (PHF or placebo) and time (samples collected pre- or post-intervention). The arrows represent the centroids of the constrained factors (arm and time) in the CCA model. Only arm was identified as a significant contributor to microbiome variation by PERMANOVA; time is shown for visualization. (B) Taxonomic composition of the 20 most abundant bacterial species across all samples, shown as relative abundances in stacked bar plots. The samples are grouped by study arm and time (placebo group before intervention, placebo group after intervention, polyherbal formulation group before intervention, and polyherbal formulation group after intervention), with taxa ordered by the mean abundance within each group. CCA: canonical correspondence analysis; PHF: polyherbal formulation.
Article Snippet: DNA extraction was performed with the MGIEasy Stool Microbiome DNA Extraction Kit on the MGISP-960 automated platform (MGI Tech Co., Ltd, China).
Techniques: Formulation